The Dire Wolf: A Lesson in Startup Basics
Easter is coming and speaking of resurrections, dire wolves, made famous by HBO’s Game of Thrones, have been extinct for around 12,500 years, but “thanks to genetic engineers at biotech company Colossal Biosciences, these majestic predators are back,” Live Science reported. The pups were even named after the dire wolves from the HBO series: Romulus, Remus, and Khaleesi.
“The company claims to have achieved this by extracting DNA from dire wolf fossils in 2021, isolating and growing gray wolf cells, and “tinkering” with the genes. They then transferred that DNA into empty canine eggs and transplanted those into fertile dogs,” Daily Dot explained.
As for this being a resurrection event, “Colossal’s critics have pointed out that, out of thousands of genetic differences that distinguish dire wolves from gray wolves, the company made only a handful of edits focused on recapitulating obvious physical traits such as fur color and texture,” Science.org reported. “Many researchers were also quick to note that according to a 2021 genetic analysis published in Nature, the dire wolf might not even be a wolf at all, belonging instead to a North American lineage of dogs that diverged from the ancestors of gray wolves more than 5 million years ago. As that study’s lead author Angela Perri told Science in 2021, the dire wolf was more closely related to the African jackal than the gray wolf and may have resembled “a giant, reddish coyote.”