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The Week in Digestion

The Week in Digestion

Provided by Schoklosters Castle and Unsplash

Last week was a difficult one between it having been the 24th anniversary of the 9/11 attacks and the assassination of Charlie Kirk. Rather than opine on the events, we will point out one thing to founders: the importance and power that’s in a name. If you name your company, say, Avalanche, which one did in the days of Web 1.0, whether as an act to defy fate or one of prescience, guess what happened? Yup, it all came tumbling down. The Bonfire Collective? Went up in smoke. Note to self: Charlie Kirk’s outlet was Turning Point and so far, from all indications, his assassination did appear to trigger something of a turning point. As always, time will tell.

In times of stress, people tend to turn to food for comfort, so let ‘s focus on food, speaking of turning points. Food and various ingredients have come under scrutiny of late. Seed oils, in particular. “For several decades, saturated fat was wrongly blamed for heart disease, while vegetable oils quietly caused a surge in obesity, inflammation, and chronic metabolic disorders. Newly appointed FDA commissioner Dr. Marty Makary is now leading efforts to revise outdated dietary guidelines that were built on cherry-picked data from Ancel Keys’ Seven Countries Study. There was just one problem with the research — Keys cherry-picked the data. He selectively chose the countries that fit his hypothesis while ignoring data from 16 other countries that went against his recommendations. Had he chosen a different set of countries, the data would have been the opposite — that increasing the percent of calories from fat actually reduces the number of deaths from coronary heart disease,” Mercola reported in The War on Saturated Fat is Finally Coming to an End.

Despite the methodological flaws in his data, the medical community accepted Keys’ study

FYI, “Seed oils, or “vegetable oils” are extracted from vegetable crops like soybeans, cottonseed, and corn,” HeartandSoil explained. “Seed oils were originally byproducts of manufacturing during the Industrial Revolution. They weren’t initially intended for the dinner table. However, by the mid-1900s, seed oils had become a staple ingredient in packaged foods, reshaping the Western diet in ways that are raising new health concerns today. The food industry favors seed oils for their low cost and so-called “heart-healthy” reputation. Research suggests that seed oils pose significant health risks. Read More...

The Human Side of the AI Discussion

The Human Side of the AI Discussion

Photo by Igor Omilaev on Unsplash

At this point, we all know that AI is not a panacea, and while it is a great tool, we wonder if it should or even could take over every job on the planet, as is so widely reported.

Are humans truly categorically replaceable?

We’re told, for example, that AIs are a better predictor of medical conditions than are doctors, but as Mercola reminds us in his piece on How Medical Superintelligence Is Revolutionizing the Future of Healthcare, “AI models tend to reflect the positions of dominant institutions like the U.S. Centers for Disease Control and Prevention (CDC) or World Health Organization (WHO). Be aware that they may emphasize conventional narratives regardless of evidence quality.” In the Covid era, Ivermectin was often demonized and referred to as a ‘horse de-wormer,’ which is how its started life. Now the medication is being effectively used to treat certain cancers and is part of the “WHO Model List of Essential Medicines.” Also keep in mind that while doctors are using AI to aid in their diagnoses, the results are only as good as the questions being asked and how they’re posed.  Are physicians receiving training in effectively using LLMs? Read More...

Is This the Age of the DonkeyCorn?

Is This the Age of the DonkeyCorn?

Photo by Daniel Fazio on Unsplash

And with all due respect to unicorns, mind you.

We came across an interesting podcast, with our bud Shira Lazar interviewing BarkBox co-founder cum Audos founder Henrik Werdelin. As USNN noted, “With the launch of Audos, Werdelin “envisions expanding the startup landscape from a few dozen ventures annually to potentially hundreds of thousands… by helping anyone—techie or not—build a million-dollar business using AI.”

This is not an endorsement of Werdelin’s new venture, but we agree with him – and have said it before ourselves – as he mentions in his soon-to-be published book, Me, My Customer and AI, which delves into the new frontier of entrepreneurship,” that “emotional connection and “relationship capital” are your moat in an age of automation.” Read More...

How to Take a SWOT at Your Own Company

How to Take a SWOT at Your Own Company

Image by OpenClipart-Vectors from Pixabay

It’s the so-called dog days. Many investors and key decision makers have ‘gone fishing,’ so to speak and while it may seem like there’s nothing going on but the rent on that front, don’t be fooled, founders: it’s SWOT season and we’re not talking about mosquitoes and sand flies, although they’re out there, too. We’re talking about that now is a good time to do a SWOT analysis, the acronym for Strengths, Weaknesses, Opportunities, Threats.

Here are some excellent guidelines from Forbes, with a few tweaks:

Strengths. “Your Strengths are internal positives about your company that you can control and that often provide you with a competitive advantage. Some examples might be the quality of your product, the effectiveness of your processes, your access to physical or team assets or other competitive advantages.” Most importantly, what’s your superpower? What are you doing, short or long term, that will put you ahead of your competitors, or will possibly even be an industry game-changer? Read More...

Did Video Just Kill the Radio Star – Again?

Did Video Just Kill the Radio Star – Again?

Image by Pikurā from Pixabay

Ok, the proverbial radio star, this time around. When the once iconic MTV first launch, the first video the network aired was the Buggles’ Video Killed the Radio Star.

And it did. That was then and this is now, and as we often warn, no one stays on top forever. Now we’re witnessing the demise of cable in favor of streaming services et al, and where is this leading?

“There was a time, not long ago, when Americans — regardless of region, class, or politics — shared a common cultural foundation,” said The American Spectator in this must-read: Gen Z Isn’t Just Online — They’re Living in Parallel Realities. “From the Saturday morning cartoons children watched to the nightly news programs adults relied on, mainstream culture was both a mirror and a glue: it reflected our values while keeping us tethered to the same national experience. That era is over. Read More...

The Founder’s Mid-Summer Must-Do List

The Founder’s Mid-Summer Must-Do List

Photo by Ksenia Makagonova on Unsplash

It’s roughly midsummer. Investment deals are still being closed, but they generally tend to slow down or in many cases, take a bit longer in summer, as investors unplug a bit for the season, or at least spend less time vetting deals. They like to kick back, too: travel, spend time with their friends and/or families and generally spend more time minding their SPFs than the latest pitch deck that just came to them over the proverbial transom.

We host an Investor Insights – online – roughly every two weeks, with a different investor each time and have done for years. You’d be surprised at the number of founders who have gotten funded by investors they’ve met at this event, which we always post in our free newsletter.

Andrew Ackerman spoke at a recent Online Investor Insights, and shared great information, as the investors we host often do, each one imparting different advice from a unique perspective – and all valid. In fact, Ackerman, who has sat on both sides of the table as both a founder and an investor, recently published a book entitled The Entrepreneur’s Odyssey (25% off discount code: TEO25) which spells out what every founder needs to know. Read More...

The Deep State of Tech

The Deep State of Tech

Image by PublicDomainPictures from Pixabay

Last week was Tech Week in New York and since AI is the fastest growing technology in human history, of course the calendar of events was all AI, all the time. We watched as audiences listened with rapt attention to speakers as they expounded upon the world of difference that various AI technologies and their applications would make to the human condition.

Once again, we will remind you that what man cannot remember he is doomed to repeat. Unfortunately, with AI in the mix, it will be repeated on steroids.

When the Age of Social dawned and Facebook, Google and the likes were establishing their beachheads, we warned back then that these were not mere platforms but rather nation-states with larger populations than any single country on the planet. Or even continent, for that matter. Those platforms are now AI-enabled – more and more so every day – and it seems that there’s no escaping that matrix. Read More...

The Dirt on Startup Essentials

The Dirt on Startup Essentials

Image by Richard Duijnstee from Pixabay

After a long, cold winter, it seems that suddenly it’s Spring when, as ee cummings wrote, “the world is puddle-wonderful,” although considering all the rain we had here on the East Coast last week, negotiating the puddles at every street corner was not so wonderful, unless you were wearing waders.

And there’s more on the way. Isn’t rain supposed to be an April thing?

But as those of us who’ve been circling the sun for a few years now well know, the sunshine always does return and once again, all is right with the world and as we also know, into every life a little rain must fall and that’s what helps to turn the grass green and what founder or investor doesn’t want to suddenly find an abundance of green in his or her life? Read More...

The Myth of the Crowded Vertical

The Myth of the Crowded Vertical

Image by Rudi Arlt from Pixabay

Disclosure: this is not a new product promotion but rather a study in how to potentially disrupt a very crowded vertical.

“A new American electric vehicle startup called Slate Auto has made its debut, and it’s about as anti-Tesla as it gets,” TechCrunch reported, once again missing the forest through the trees, and proving yet again that the tech media loves to get their digs in, whether it’s appropriate or not.

While there are current Tesla owner who are experiencing buyer’s remorse, or as the New York Times wrote, “In Marin County, There’s Trouble in Teslaville,” is the main selling point of the Slate the fact that it isn’t a Tesla? Or maybe the fact that “It’s affordable, deeply customizable, and very analog. It has manual windows, and it doesn’t come with a main infotainment screen. Heck, it isn’t even painted. It can also  transform from a two-seater pickup to a five-seater SUV,” as TechCrunch pointed out. Read More...

The Dire Wolf: A Lesson in Startup Basics

The Dire Wolf: A Lesson in Startup Basics

Image by Dušan from Pixabay

Easter is coming and speaking of resurrections, dire wolves, made famous by HBO’s Game of Thrones, have been extinct for around 12,500 years, but “thanks to genetic engineers at biotech company Colossal Biosciences, these majestic predators are back,” Live Science reported. The pups were even named after the dire wolves from the HBO series: Romulus, Remus, and Khaleesi.

“The company claims to have achieved this by extracting DNA from dire wolf fossils in 2021, isolating and growing gray wolf cells, and “tinkering” with the genes. They then transferred that DNA into empty canine eggs and transplanted those into fertile dogs,” Daily Dot explained.

As for this being a resurrection event, “Colossal’s critics have pointed out that, out of thousands of genetic differences that distinguish dire wolves from gray wolves, the company made only a handful of edits focused on recapitulating obvious physical traits such as fur color and texture,” Science.org reported. “Many researchers were also quick to note that according to a 2021 genetic analysis published in Nature, the dire wolf might not even be a wolf at all, belonging instead to a North American lineage of dogs that diverged from the ancestors of gray wolves more than 5 million years ago. As that study’s lead author Angela Perri told Science in 2021, the dire wolf was more closely related to the African jackal than the gray wolf and may have resembled “a giant, reddish coyote.” Read More...